Selected publications:

Zárybnický T, Heikkinen A, Kangas SM, Karikoski M, Martínez-Nieto GA, Salo MH, Uusimaa J, Vuolteenaho R, Hinttala R, Sipilä P, Kuure S. Modeling Rare Human Disorders in Mice: The Finnish Disease Heritage. Cells 2021, 10, 3158. https://doi.org/10.3390/cells10113158

Sipilä P, Junnila A, Hakkarainen J, Huhtaniemi R, Mairinoja L, Zhang FP, Strauss L, Ohlsson C, Kotaja N, Huhtaniemi I, Poutanen M. The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency. FASEB J. 2020 May;34(5):6111-6128.
https://pubmed.ncbi.nlm.nih.gov/32190925/

Zhang F-P, Malinen M, Mehmood A, Lehtiniemi T, Jääskeläinen T, Korhonen H, Laiho A, Elo L, Ohlsson C, Kotaja N, Poutanen M, Sipilä P*, Palvimo J*. Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction. Nature Communications 2019 Feb 15;10(1):777, * equal contribution
https://pubmed.ncbi.nlm.nih.gov/30770815/

Wu J, Movérare-Skrtic S, Zhang FP, Koskela A, Tuukkanen J, Palvimo JJ, Sipilä P, Poutanen M, Ohlsson C. Androgen receptor SUMOylation regulates bone mass in male mice. Mol Cell Endocrinol. 2018 Sep 24. pii: S0303-7207(18)30278-8
https://pubmed.ncbi.nlm.nih.gov/30261210/

Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala TD, Aittokallio T, Laiho A, Elo L, Ohlsson C, Kallio P, Mäkelä S, Mustonen MVJ, Sipilä P, Poutanen M. Adrenals contribute to growth of castration-resistant VCaP prostate cancer xenografts. Am J Pathol. 2018 Dec;188(12):2890-2901.
https://pubmed.ncbi.nlm.nih.gov/30273606/

Knuuttila M, Mehmood A, Mäki-Jouppila J, Ryberg H, Taimen P, Knaapila J, Ettala O, Boström PJ, Ohlsson C, Venäläinen MS, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. Intratumoral androgen levels are linked to TMPRSS2-ERG fusion in prostate cancer. Endocrine-Related Cancer 2018 25:807-819.
https://pubmed.ncbi.nlm.nih.gov/29773553/

Hakkarainen J, Zhang F-P, Cisneros Montalvo S, Nurmio M, Toppari J, Ohlsson C, Kotaja N, Sipilä P, Poutanen M. Hydroxysteroid (17β) dehydrogenase 1 expressed by Sertoli cells contributes to steroid synthesis and is required for male fertility. FASEB J 2018 Jun;32(6):3229-3241 doi: 10.1096/fj.201700921R
https://pubmed.ncbi.nlm.nih.gov/29401623/

Knuuttila M, Mehmood A, Huhtaniemi R, Häkkinen MR, Oksala R, Laajala TD, Ryberg H, Handelsman DJ, Aittokallio T, Auriola S, Ohlsson C, Laiho A, Elo LL, Sipilä P, Mäkelä SI, Poutanen M. Antiandrogens reduce intratumoral androgen concentrations and induce androgen receptor expression in castration-resistant prostate cancer xenografts. Am J Pathol. 2018 Jan;188(1):216-228.
https://pubmed.ncbi.nlm.nih.gov/29126837/

Björkgren I, Alvarez L, Blank N, Balbach M, Turunen H, Laajala TD, Toivanen J, Krutskikh A, Wahlberg N, Huhtaniemi I, Poutanen M, Wachten D, Sipilä P. Targeted inactivation of the mouse epididymal beta-defensin 41 alters sperm flagellar beat pattern and zona pellucida binding. Mol Cell Endocrinol. 2016 May 15;427:143-54.
https://pubmed.ncbi.nlm.nih.gov/26987518/

Björkgren I, Gylling H, Turunen H, Huhtaniemi I, Strauss L, Poutanen M and Sipilä P. Imbalanced lipid homeostasis in the conditional Dicer1 knock-out mouse epididymis causes instability of the sperm membrane. FASEB J, 2014 29:433-42.
https://pubmed.ncbi.nlm.nih.gov/25366345/

Björkgren I, Saastamoinen L, Krutskikh A, Huhtaniemi I, Poutanen M and Sipilä P. Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One, 2012 7(6):e38457.
https://pubmed.ncbi.nlm.nih.gov/22701646/